ABSTRACT
Objective: To evaluate the impact of mean platelet volume (MPV) on prognosis in patients with ST-segment elevation myocardial infarction (STEMI). Methods: A total of 1012 consecutive STEMI patients received percutaneous coronary intervention (PCI) in our hospital from 2010-01-01 to 2014-10-31 were enrolled. Major adverse cardiovascular events (MACE) were recorded in 2015-10. Based on ROC curve measured optimal critical point of MPV in all-cause death, the patients were divided into Low MPV group and High MPV group. The incidence of MACE was compared between 2 groups, the impact of MPV on prognosis of PCI treated STEMI patients was studied by uni- and multivariate COX regression analysis. Results: By ROC curve, the optimal critical point of MPV in all-cause death was MPV≤9. 466 fl. MPV≤9. 466 fl in Low MPV group, n=549 and MPV>9. 466 fl in High MPV group, n=463. The patients were followed-up for 34 (12-69) months. Compared with Low MPV group, the patients in High MPV group had the higher incidences of all-cause death and cardiac death, P<0. 001 and P=0. 001. With adjusted multivariates, COX regression analysis showed that MPV was an independent risk factor of all-cause death (HR=1. 463, P<0. 001) and cardiac death (HR=1. 458, P<0. 001) in relevant patients. Conclusions: Increased MPV at admission had the predictive value for long-term prognosis in PCI treated STEMI patients.
ABSTRACT
Objective: To analyze gender differences for the long-term prognosis in patients with chronic heart failure (CHF). Methods: A total of 925 consecutive CHF patients admitted in our hospital were enrolled those including 460 (49.7％) female. The mean follow-up time was 3.4 years and the end point event was all-cause mortality. Gender differences for the long-term prognosis in CHF patients were studied by Cox proportional-hazards regression analysis. Results: The overall all-cause mortality was 27.9％ during follow-up period, mortality in female was 25.2％ and in male was 30.5％. Multivariate Cox regression analysis presented that the long-term death risk in male patients was higher than female (HR=1.309, 95％ CI 1.002-1.708, P=0.048). Subgroup analysis showed that for patients age≥65 years, LVEF<45％and with NYHA grade III/IV, the long-term prognosis in female was much better than male. Conclusion: Long-term prognosis of CHF in female patients was better than male; female at age≥65 years, LVEF<45％and NYHA grade III/IV had the better prognosis.
ABSTRACT
Objective: To analyze gender differences for the long-term prognosis in patients with chronic heart failure (CHF). Methods: A total of 925 consecutive CHF patients admitted in our hospital were enrolled those including 460 (49.7％) female. The mean follow-up time was 3.4 years and the end point event was all-cause mortality. Gender differences for the long-term prognosis in CHF patients were studied by Cox proportional-hazards regression analysis. Results: The overall all-cause mortality was 27.9％ during follow-up period, mortality in female was 25.2％ and in male was 30.5％. Multivariate Cox regression analysis presented that the long-term death risk in male patients was higher than female (HR=1.309, 95％ CI 1.002-1.708, P=0.048). Subgroup analysis showed that for patients age≥65 years, LVEF<45％and with NYHA grade III/IV, the long-term prognosis in female was much better than male. Conclusion: Long-term prognosis of CHF in female patients was better than male; female at age≥65 years, LVEF<45％and NYHA grade III/IV had the better prognosis.